| Home | vs. | Away |
| Tottenham Hotspur | vs. | Wycombe Wanderers |
| Derby County | vs. | Leicester City |
| Oxford United | vs. | Birmingham City or Newcastle United |
| Sutton United or AFC Wimbledon | vs. | Leeds United |
| Liverpool or Plymouth Argyle | vs. | Wolverhampton Wanderers |
| Norwich City or Southampton | vs. | Arsenal |
| Ipswich Town or Lincoln City | vs. | Brighton & Hove Albion |
| Chelsea | vs. | Brentford |
| Manchester United | vs. | Wigan Athletic |
| Millwall | vs. | Watford |
| Rochdale | vs. | Huddersfield Town |
| Sunderland or Burnley | vs. | Bristol City or Fleetwood Town |
| Blackburn Rovers | vs. | Blackpool or Barnsley |
| Fulham | vs. | Hull City |
| Middlesbrough | vs. | Accrington Stanley |
| Bolton Wanderers or Crystal Palace | vs. | Manchester City |
FA Cup 2016-17: Fourth-Round arrangement
